Margo Emont

Research

My work aims to explore the the heterogeniety of adipose tissue and of adipocytes themselves.

Highlighted

A single cell atlas of human and mouse white adipose tissue
A single cell atlas of human and mouse white adipose tissue
Margo P. Emont, Christopher Jacobs, Adam L. Essene, Deepti Pant, Danielle Tenen, ..., Antonio Giordano, Orr Ashenberg, Aviv Regev, Linus T. Tsai, Evan D. Rosen
Nature   ·   16 Mar 2022   ·   doi:10.1038/s41586-022-04518-2

All

2023

Author Correction: A single-cell atlas of human and mouse white adipose tissue
Author Correction: A single-cell atlas of human and mouse white adipose tissue
Margo P. Emont, Christopher Jacobs, Adam L. Essene, Deepti Pant, Danielle Tenen, ..., Antonio Giordano, Orr Ashenberg, Aviv Regev, Linus T. Tsai, Evan D. Rosen
Nature   ·   26 Jul 2023   ·   doi:10.1038/s41586-023-06445-2
Exploring the heterogeneity of white adipose tissue in mouse and man
Exploring the heterogeneity of white adipose tissue in mouse and man
Margo P Emont, Evan D Rosen
Curr Opin Genet Dev.   ·   01 Jun 2023   ·   10.1016/j.gde.2023.102045

2022

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
Haopeng Xiao, Luiz H.M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, ..., Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Cell   ·   01 Nov 2022   ·   doi:10.1016/j.cell.2022.10.003
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of <i>Ppp2r1b</i>
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b
Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, ..., Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen
Science Translational Medicine   ·   23 Mar 2022   ·   doi:10.1126/scitranslmed.abh3831
A single cell atlas of human and mouse white adipose tissue
A single cell atlas of human and mouse white adipose tissue
Margo P. Emont, Christopher Jacobs, Adam L. Essene, Deepti Pant, Danielle Tenen, ..., Antonio Giordano, Orr Ashenberg, Aviv Regev, Linus T. Tsai, Evan D. Rosen
Nature   ·   16 Mar 2022   ·   doi:10.1038/s41586-022-04518-2

2021

A single cell atlas of human and mouse white adipose tissue (preprint)
A single cell atlas of human and mouse white adipose tissue (preprint)
Margo P. Emont, Christopher Jacobs, Adam L. Essene, Deepti Pant, Danielle Tenen, ..., Antonio Giordano, Orr Ashenberg, Aviv Regev, Linus T. Tsai, Evan D. Rosen
bioRxiv   ·   11 Nov 2021   ·   doi:10.1101/2021.11.09.466968
Mesothelial cells are not a source of adipocytes in mice
Mesothelial cells are not a source of adipocytes in mice
Gregory P. Westcott, Margo P. Emont, Jin Li, Christopher Jacobs, Linus Tsai, Evan D. Rosen
Cell Reports   ·   01 Jul 2021   ·   doi:10.1016/j.celrep.2021.109388

2020

Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation
Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation
Heejin Jun, Yingxu Ma, Yong Chen, Jianke Gong, Shanshan Liu, ..., Xiaona Qiao, Margo P. Emont, X.Z. Shawn Xu, Shingo Kajimura, Jun Wu
Developmental Cell   ·   01 Jul 2020   ·   doi:10.1016/j.devcel.2020.05.017

2019

Development, activation, and therapeutic potential of thermogenic adipocytes
Development, activation, and therapeutic potential of thermogenic adipocytes
Margo P. Emont, Dong-il Kim, Jun Wu
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids   ·   01 Jan 2019   ·   doi:10.1016/j.bbalip.2018.05.004

2018

An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling
An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling
Heejin Jun, Hui Yu, Jianke Gong, Juan Jiang, Xiaona Qiao, ..., Jianfeng Liu, Robert T. Kennedy, Ivan Maillard, X. Z. Shawn Xu, Jun Wu
Nature Medicine   ·   21 May 2018   ·   doi:10.1038/s41591-018-0032-8
HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16
HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16
Jiling Liao, Juan Jiang, Heejin Jun, Xiaona Qiao, Margo P Emont, Dong-il Kim, Jun Wu
Endocrinology   ·   10 May 2018   ·   doi:10.1210/en.2018-00257
Isolation and Differentiation of Murine Primary Brown/Beige Preadipocytes
Isolation and Differentiation of Murine Primary Brown/Beige Preadipocytes
Hui Yu, Margo Emont, Heejin Jun, Jun Wu
Adipose-Derived Stem Cells   ·   01 Jan 2018   ·   doi:10.1007/978-1-4939-7799-4_21

2017

Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming
Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming
Juan Jiang, Margo P. Emont, Heejin Jun, Xiaona Qiao, Jiling Liao, Dong-il Kim, Jun Wu
Metabolism   ·   01 Dec 2017   ·   doi:10.1016/j.metabol.2017.08.006
The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice
The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice
Abdul Soofi, Katherine I. Wolf, Margo P. Emont, Nathan Qi, Gabriel Martinez-Santibanez, Edward Grimley, Wesam Ostwani, Gregory R. Dressler
Journal of Biological Chemistry   ·   01 Jun 2017   ·   doi:10.1074/jbc.m116.771428
Isolation of Mouse Stromal Vascular Cells for Monolayer Culture
Isolation of Mouse Stromal Vascular Cells for Monolayer Culture
Longhua Liu, Louise D. Zheng, Sarah R. Donnelly, Margo P. Emont, Jun Wu, Zhiyong Cheng
Thermogenic Fat   ·   01 Jan 2017   ·   doi:10.1007/978-1-4939-6820-6_2

2015

Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro.
Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro.
Margo P Emont, Hui Yu, Heejin Jun, Xiaowei Hong, Nenita Maganti, Jan P Stegemann, Jun Wu
Endocrinology   ·   01 Dec 2015   ·   pmid:26425808
Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes
Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes
Margo P. Emont, Stelios Mantis, Jonathan H. Kahn, Michael Landeche, Xuan Han, Robert M. Sargis, Ronald N. Cohen
Molecular and Cellular Endocrinology   ·   01 May 2015   ·   doi:10.1016/j.mce.2015.03.002
Transcriptional control and hormonal response of thermogenic fat
Transcriptional control and hormonal response of thermogenic fat
Margo P Emont, Hui Yu, Jun Wu
Journal of Endocrinology   ·   24 Mar 2015   ·   doi:10.1530/JOE-15-0026

2014

Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain
Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain
Marcella K. Vaicik, Jill Thyboll Kortesmaa, Sofia Movérare-Skrtic, Jarkko Kortesmaa, Raija Soininen, ..., Björn Rozell, Margo Emont, Ronald N. Cohen, Eric M. Brey, Karl Tryggvason
PLoS ONE   ·   13 Oct 2014   ·   doi:10.1371/journal.pone.0109854